|
Craniofacial Abnormalities
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Missense, nonsense, and splice mutations in the Fibroblast Growth Factor 8(FGF8) have recently been identified in patients with hypothalamo-pituitary dysfunction and craniofacial anomalies.
|
24280688 |
2014 |
|
Craniofacial Abnormalities
|
0.320 |
Biomarker
|
group |
BEFREE |
Since FGF8 maps to the same chromosomal region as FGFR2, has indeed been shown to be a ligand for FGFR2, and has an expression pattern consistent with limb and craniofacial anomalies, we have screened two kindreds with Pfeiffer syndrome that were previously linked to markers from 10q24-25 and a large number of individuals with craniosynostosis and limb anomalies for mutations in the coding sequence of FGF8.
|
9332670 |
1997 |
|
Craniofacial Abnormalities
|
0.320 |
Biomarker
|
group |
CTD_human |
Fgf8 is required for anterior heart field development.
|
16720880 |
2006 |
|
Cardiovascular Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Fgf8 is required for anterior heart field development.
|
16720880 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased expression of FGF8 correlated significantly with higher Gleason scores (P=0.0004) and advanced tumour stage (P=0.0016).
|
10348350 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Previously, we described cloning of three alternatively spliced mRNA forms of human FGF8, a, b, and e, of which the b form is the major expressed species in both normal and tumor prostatic epithelial cells.
|
9525747 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors.
|
30079292 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The reverse transcription-PCR amplification method, however, detected FGF8 mRNA expression in adult prostate, kidney, and testes (the tissues that were tested) and in all normal and tumor prostatic epithelial cell lines examined; although expression of both FGF8a and FGF8b was seen in kidney and testes, FGF8b appeared to be the predominantly expressed species in the prostatic tissue and cell lines analyzed by reverse transcription-PCR.
|
8891346 |
1996 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Consistent with the oncogenic characteristics of FGF-8, the corresponding mRNA was detected in the human prostate tumour cell lines LNCaP and DU145.
|
8645626 |
1996 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These regions contained representative tumor-related genes, such as the FGF8 and NPM3 genes at 10q24.32, and the LAMP1 gene at 13q34, which have been reported in connection with various tumors.
|
20428766 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In 39 tumours there was a statistically significant negative correlation between tumour grade and FGF8 expression and a positive correlation between FGF8 and androgen receptor expression.
|
10343609 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with this, FGF8 can also promote tumor growth and metastasis in mouse models.
|
25473897 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In general, the increased intensity of FGF-8 staining was associated with loss of differentiation within the tumors (Bowker's test, p = 0.37).
|
11072239 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The androgen-inducible expression of Fgf8 in this tumor controls its androgen-dependent phenotype, thus stimulating interest in this gene as a possible factor in human prostate cancer and other androgen-sensitive cancers.
|
16252261 |
2006 |
|
Osteochondrodysplasias
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Gait abnormality
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Expression of fibroblast growth factor 8 (FGF-8) is increased in several forms of hormonal cancer.
|
20370578 |
2010 |
|
Malignant Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
This was tested by means of fluorescent in situ hybridisation in 20 cancer specimens to map the FGF8 gene locus.
|
12778074 |
2003 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, the FGF8 subfamily supports the development and progression of hepatocellular malignancy.
|
21319186 |
2011 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
However, the FGF-8 receptor showed greater involvement at the beginning of the malignancy alterations.
|
23362007 |
2013 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
To study the role of fibroblast growth factor 8 (FGF-8) in human development and malignancies, we have isolated and characterized its gene.
|
9366493 |
1997 |
|
Prostatic Neoplasms
|
0.040 |
AlteredExpression
|
group |
LHGDN |
FGF-8 is involved in bone metastasis of prostate cancer.
|
18386787 |
2008 |
|
Prostatic Neoplasms
|
0.040 |
AlteredExpression
|
group |
LHGDN |
FGF8 isoform b expression in human prostate cancer.
|
12778074 |
2003 |
|
Prostatic Neoplasms
|
0.040 |
AlteredExpression
|
group |
LHGDN |
Regulation of FGF8 expression by the androgen receptor in human prostate cancer.
|
12140757 |
2002 |